I see this as a Problem: "because the business is a s-corp."

You don't get to take Home Office deduction as an employee of an S Corp. You told us this is a personal residence, not a Corporate owned office. You told us you know what it states on the title. And you don't get to take this deduction, since the tax laws changed for TCJA 2017.

Employees are supposed to submit for reimbursement to the employer under An Accountable Plan for costs. Depreciation isn't going to be any part of this.