You can RDP to a physical or virtual desktop without having to worry about your destination for client data files.  If you host your client data in the cloud, there're a number of solutions that allow you to mount it as a network drive, so that everyone is accessing the same set of data, whether in or out of office.  Either way, you may experience some performance issues, depending on your internet connections on both ends, bandwidth, and system resources.  The former, however, would probably be easier to set up.

Hopefully, others with relevant experience in PS would come by and give you more pointed suggestions.