Makes sense to keep data files separate from program files.  You can follow the instructions in this article to set up the data path for all machines: https://accountants-community.intuit.com/articles/1861960-set-up-or-change-the-data-path-in-lacerte

If you, for some reason, want to change this machine-by-machine, you can find this within Lacerte under Settings / Master Options / Setpup / Program Options.