Today after a considerable time on the phone with support we solved the problem.  What we finally did was save the return with a different number in my case or you could use a different name.  Then opened the new return and ran all the normal protocols, review etc. Then went to EF center and filed it.  Wala!  It transmitted.  So the issue was the file must have been corrupted somehow.  Support is saying it might be the virus software, but I doubt that since I use Microsoft Office 365 with the virus software of theirs and have never had an issue and have file dozens of returns already, both before and after this return.

So try saving your file as another and then use that file to transmit.

Good Luck