This cleared it up:
YY Represents the tax year in which you are working and X represents the network drive in which your ProSeries program is installed.

    Locate all files beginning with ~$, cut and paste files into a new folder on the desktop.
    Navigate to the Common Folder.
        ProSeries Professional Directory: C:\ProWinYY\Common
        ProSeries Network Directory: X:\ProSeries\ProNetYY\Common
        ProSeries Basic Directory: C:\BasWinYY\Common
    Delete files ~Users.lck and Users.net
    Close the File Explorer.
    Select Start and All Programs.
    Select ProSeries 20YY and HomeBase Tuneup.
    Launch the program and attempt to open the client file.